The Top Five Challenges for Commercial HVAC service at a Lab
March 4th, 2025
4 min read
By Lisa Flynn

Working on HVAC systems in laboratories is not just about heating and cooling—it’s about maintaining precise conditions that ensure safety and the success of critical research. If the temperature fluctuates, if contaminants spread, or if air pressure isn’t controlled, the results can be catastrophic—failed experiments, damaged equipment, and even health hazards for lab personnel.
At Harold Brothers, we’ve worked with laboratories of all sizes, helping them meet strict environmental and safety standards. Our expertise in laboratory HVAC systems has shown us that there are five major challenges every technician must be prepared to face.
In this article, we’ll break down these challenges and give you practical solutions to ensure your lab’s HVAC system runs efficiently and safely.
1. Keeping the Temperature and Humidity in your Lab Just Right
In a regular home or office, small temperature changes are not a big deal. However, even a tiny change in temperature or humidity can cause big problems in a laboratory.
Some experiments need very exact conditions to work properly. If the temperature or humidity goes too high or too low, the experiment could fail.
Also, some sensitive equipment can get damaged if the air is too dry or too humid.
Why This Is a Challenge
- Laboratories need very precise climate control.
- Small temperature changes can ruin experiments.
- High or low humidity can damage equipment or affect research results.
How to Fix It
- Regularly check and calibrate thermostats and sensors.
- Install and maintain humidifiers and dehumidifiers.
- Use real-time monitoring systems to catch problems quickly.
2. Following Safety and Air Quality Rules in highly controlled Lab settings
Labs have strict rules about how air should move and be cleaned to keep people safe. Different groups, like OSHA (Occupational Safety and Health Administration) and ASHRAE (American Society of Heating, Refrigerating, and Air-Conditioning Engineers), set rules to make sure lab air is clean and safe.
Why This Is a Challenge
- Labs use chemicals and other materials that can be dangerous if not properly ventilated.
- There are many different safety rules to follow.
- HVAC systems must meet special air quality standards.
How to Fix It
- Stay updated on safety rules and regulations.
- Perform regular inspections to check that air is being cleaned and moved properly.
- Ensure ventilation systems meet required safety standards.
3. Controlling Air Contaminants and Filtration
Many laboratories work with chemicals, bacteria, and other materials that should not get into the air. To keep the air safe, labs use special filters and ventilation systems.
Think of it like a high-tech kitchen exhaust fan designed to keep smoke and odors from filling the house. But instead of just removing smells, the lab's ventilation systems are designed to handle far more dangerous substances—like the fumes from chemicals or pathogens from bacteria and viruses.
The filters in these systems are often multi-stage, designed to trap particles as small as possible, sometimes down to a fraction of a micron. The air is filtered and purified before it's released back into the environment, ensuring that nothing harmful escapes.
Without these specialized systems, labs would become hazardous places to work, not just for the people inside, but for the entire community nearby.
Why This Is a Challenge
- If filters get clogged, dangerous substances could spread through the air.
- Different labs need different types of filters.
- Some air contaminants are too small to see, making them harder to control.
How to Fix It
- Regularly replace air filters, such as HEPA filters, to keep air clean.
- Check and maintain exhaust systems, like fume hoods and biosafety cabinets.
- Test air quality to make sure contaminants are being removed properly.
4. Managing Air Pressure to Keep Employees Safe
Some labs need positive air pressure to keep harmful substances out, while others need negative air pressure to keep dangerous materials from escaping. If the air pressure is not balanced correctly, harmful chemicals or germs could spread to other areas.
Why This Is a Challenge
- Labs need specific air pressure levels, which must be maintained at all times.
- If pressure is too high or too low, harmful substances may move to unsafe areas.
- Air pressure changes can be caused by small HVAC system issues.
How to Fix It
- Use pressure monitoring equipment to check levels regularly.
- Adjust dampers and airflow systems to maintain correct pressure.
- Fix leaks in the ventilation system that could cause pressure problems.
5. Working with Complex HVAC Systems in Clinical Settings
Laboratory HVAC systems are much more complicated than those in homes or offices. They are connected to many other systems, such as chemical exhaust systems, clean rooms, and energy recovery systems. Each part must work correctly to keep the lab safe and functional.
It’s like a symphony orchestra—each instrument (or system) has a specific role, and they must all be in sync. If one section plays out of tune or at the wrong time, the entire performance is disrupted. Similarly, if one component of the lab’s HVAC system fails, it can affect safety, air quality, and overall functionality
Why This Is a Challenge
- Laboratory HVAC systems are more advanced and harder to fix than regular systems.
- Problems in one part of the system can cause issues in other areas.
- Specialized training is needed to understand and repair lab HVAC systems.
How to Fix It
- Get specialized training to learn how lab HVAC systems work.
- Use advanced tools to diagnose and repair problems.
- Work closely with lab managers to ensure systems are running properly.
Mastering the Challenges of Laboratory HVAC Systems
Servicing HVAC systems in laboratories comes with unique and complex challenges, but understanding these issues is the first step toward solving them. From precise climate control to ensuring proper air filtration, every detail matters.
You came here looking for solutions to common HVAC challenges in lab environments, and now you have a clear roadmap for handling them. Whether it’s maintaining air pressure, following strict safety standards, or dealing with highly specialized systems, you now know the key factors that can make or break lab HVAC performance.
If you’re facing issues with your laboratory’s HVAC system, our team at Harold Brothers is here to help. We offer expert guidance, system evaluations, and maintenance services to ensure your facility meets all necessary regulations.
Contact us today for a consultation, and in the meantime, learn about the importance of an HVAC Maintenance Contract for keeping your systems safe, reliable and up to par with regulation.
With over 39 years of experience in the HVAC industry, Lisa Flynn brings a wealth of knowledge, reliability, and proven leadership to every project. She has a demonstrated track record of managing and mentoring HVAC service technicians while collaborating closely with project managers to ensure the successful execution of construction projects. Lisa's expertise spans a broad range of critical functions, including dispatching service calls, budget preparation and management, billing and collections, and project quoting. She has cultivated strong client and customer relationships through her attention to detail and commitment to delivering exceptional results. From marketing and advertising initiatives to equipment procurement, tracking, and project close-outs, Lisa consistently drives efficiency and excellence at every stage. Her hands-on approach and dedication to exceeding expectations make her a trusted partner for clients and colleagues alike.
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